Multiple IVF Failures: Causes & Solutions
What is Repeated IVF Failure?
Repeated IVF failure is defined as the inability to achieve a clinical pregnancy after transferring at least four good-quality embryos across three or more fresh or frozen IVF cycles in women under 40. While implantation rates in most ART (Assisted Reproductive Technology) clinics range between 40–60%, success may vary depending on various clinical and biological factors.
Common Causes of Repeated IVF Failure
Despite the use of high-quality embryos, several underlying factors may impact IVF success:
- High Sperm DNA Fragmentation Index (DFI) – Damaged sperm DNA reduces embryo quality.
- Intrauterine Adhesions – Scar tissue inside the uterus can prevent embryo implantation.
- Uterine Abnormalities – Congenital structural issues can interfere with embryo attachment.
- Hydrosalpinx – Fluid from blocked fallopian tubes can harm embryo development.
- Fibroids & Adenomyosis – These conditions affect the uterine lining and receptivity.
- Thin Endometrium – A thin uterine lining makes successful implantation less likely.
- Endometrial Receptivity Issues – Poor timing or response of the uterine lining.
- Autoimmune Disorders – Autoantibodies may interfere with embryo survival.
- Immunological Factors – Abnormal immune responses may reject the embryo.
- High BMI – Obesity may reduce hormonal balance and IVF success.
- Polyps – Uterine growths may prevent implantation or cause miscarriages.
- Oocyte Aneuploidy – More common with advanced maternal age, affecting embryo genetics.
- Parental Chromosomal Abnormalities – Can lead to embryo development failure.
Precautions During IVF Treatment
To enhance your chances of success, follow these essential guidelines:
- Take all injections and prescribed medications on time.
- Avoid sexual activity after 6–7 days of stimulation.
- Quit smoking, alcohol, and recreational substances.
- Refrain from heavy lifting or high-impact physical activity.
- Maintain a balanced, nutrient-rich diet.
- Practice relaxation techniques like meditation and yoga to reduce stress.
Overcoming Repeated IVF Failures: What Can Be Done?
The first step is diagnosing the root cause through comprehensive testing:
- Hysteroscopy: Detects internal uterine issues.
- Endometrial Receptivity Array (ERA): Determines the optimal time for embryo transfer based on uterine receptivity.
- Genetic Screening: Identifies chromosomal or egg quality issues.
- Advanced Sperm Selection (MACS, IMSI, PICSI): Helps reduce the impact of high sperm DFI by selecting healthier sperm for fertilization.
Lifestyle Matters Too
Alongside medical interventions, lifestyle changes play a vital role in improving IVF outcomes:
- Eat a fertility-friendly diet rich in antioxidants, omega-3s, and vitamins.
- Exercise moderately—yoga and walking are highly recommended.
- Prioritize mental wellness through mindfulness or therapy.
- Ensure both partners are involved in maintaining a healthy lifestyle.
