Sequential Embryo Transfer

Sequential Embryo Transfer (SET)

A Dual-Stage IVF Approach to Maximize Implantation Success

What is Sequential Embryo Transfer?

Sequential Embryo Transfer (SET) is an advanced IVF technique where two sets of embryos are transferred into the uterus at different developmental stages within the same menstrual cycle. This dual-stage transfer—typically on Days 2–3 and again on Days 5–6—aims to enhance the chances of successful implantation and pregnancy.

SET has gained global acceptance and is increasingly practiced in India, especially for patients with previous implantation failures or complex infertility issues.

How Does the Procedure Work?

The SET process involves:

• Day 2–3 Transfer: Early-stage embryos (cleavage stage) are selected and transferred into the uterus.
• Day 5–6 Transfer: A second set of embryos, cultured further to the blastocyst stage, are transferred. These mature embryos release cytokines that help improve the uterine lining and promote implantation.

This staggered approach increases the chances that at least one embryo will implant successfully in a receptive uterine environment.

Who Should Consider SET?

• Women with repeated IVF or implantation failures
• Individuals with unexplained infertility
• Patients over 35 or those with a diminished ovarian reserve
• Couples aiming to maximize implantation without increasing embryo quantity in a single transfer

Lifestyle Tips for Better Outcomes

• Choose an experienced IVF specialist and clinic
• Follow a balanced, nutrient-rich diet
• Include folic acid, iron, and vitamin supplements
• Maintain a physically active and stress-free lifestyle

These changes can significantly enhance embryo quality and uterine receptivity.

Benefits of Sequential Embryo Transfer

• Increases implantation success rate
• Improves pregnancy outcomes, especially in difficult cases
• Offers better synchronization with the uterine lining
• Maintains a controlled rate of multiple pregnancies